Chronic diarrhea is defined as diarrhea that lasts for more than four weeks. It can be a debilitating condition that affects the quality of life of those who suffer from it. 

Causes of Chronic Diarrhea

There are several potential causes of chronic diarrhea, including:

Inflammatory Bowel Disease (IBD)

IBD is a group of conditions that cause inflammation in the digestive tract. The two main types of IBD are Crohn’s disease and ulcerative colitis. Both conditions can cause chronic diarrhea and other symptoms such as abdominal pain and weight loss.

Inflammatory Bowel Disease (IBD) is a group of chronic inflammatory conditions that affect the gastrointestinal tract. The two main types of IBD are Crohn’s disease and ulcerative colitis. Both conditions can cause similar symptoms, but they affect different parts of the gut and have different causes.

Crohn’s disease can affect any part of the gastrointestinal tract, from the mouth to the anus, but it most commonly affects the small intestine and the beginning of the large intestine. The inflammation caused by Crohn’s disease can lead to the formation of deep ulcers, which can cause pain, diarrhea, and bleeding.

Ulcerative colitis, on the other hand, is limited to the large intestine and the rectum. The inflammation caused by ulcerative colitis results in shallow ulcers that can cause diarrhea, rectal bleeding, and abdominal pain.

The exact cause of IBD is unknown, but it is believed to be caused by genetic, environmental, and immune factors. Some research suggests that IBD may be triggered by an abnormal immune response to the bacteria that live in the gut.

Symptoms of IBD can vary depending on the type of IBD and the location of the inflammation. Common symptoms include:

  • Abdominal pain and cramping
  • Diarrhea, which can be bloody
  • Fatigue
  • Loss of appetite and weight loss
  • Anemia
  • Rectal bleeding
  • The urgency to have a bowel movement

IBD can also lead to other complications, such as malnutrition, joint pain, skin problems, and eye inflammation. In severe cases, it can cause bowel obstruction, fistulas (abnormal connections between different organs or between an organ and the skin), or even colon cancer.

Diagnosis of IBD typically begins with a physical examination and a review of the patient’s medical history. The doctor may also order blood tests, stool tests, and imaging studies such as colonoscopy and CT scan to help identify the underlying condition.

Treatment for IBD typically involves a combination of medications to reduce inflammation and suppress the immune system and lifestyle changes such as diet, exercise, and stress management. Medications used to treat IBD include:

  • 5-aminosalicylates (5-ASA)
  • Corticosteroids
  • Immunomodulators
  • Biologic therapy
  • In severe cases, surgery may be necessary to remove the damaged portion of the intestine.

Dietary changes can also help manage IBD. Some people with IBD may find that certain foods, such as high-fiber foods, dairy products, or spicy foods, can worsen their symptoms. A dietitian can help patients with IBD develop a diet plan tailored to their needs.

It’s important to note that IBD is a chronic condition, and there is no cure for it. However, with appropriate treatment and management, most people with IBD can achieve remission and lead a normal, healthy life.

It is also important for people with IBD to work closely with their healthcare team, including a gastroenterologist, a dietitian, a nurse, and a mental health professional, to manage the disease and prevent complications.

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Celiac Disease

Celiac disease is a chronic autoimmune disorder that affects the small intestine. It is triggered by consuming gluten, wheat, barley, and rye protein. When a person with celiac disease consumes gluten, their immune system mistakenly attacks the villi, the small finger-like projections that line the small intestine. This damage to the villi impairs the absorption of nutrients, leading to a wide range of symptoms.

Symptoms of celiac disease can vary widely and range from mild to severe. Some people with celiac disease may have no symptoms at all, while others may experience symptoms such as:

  1. This is one of the most common symptoms of celiac disease. It occurs because the damage to the villi makes it difficult for the body to absorb liquids and nutrients, leading to loose and frequent stools.
  2. Many people with celiac disease experience abdominal pain and bloating, which can be caused by inflammation in the small intestine.
  3. People with celiac disease may feel tired and weak due to the malabsorption of nutrients.
  4. Celiac disease can cause various nutritional deficiencies, including anemia, osteoporosis, and vitamin deficiencies.
  5. Some people with celiac disease develop a skin rash called dermatitis herpetiformis.
  6. Other symptoms of celiac disease may include weight loss, delayed growth, and dental enamel defects.

Diagnosis of the celiac disease typically begins with a blood test to detect antibodies associated with the disease. If the test is positive, a small intestine biopsy will be done to confirm the diagnosis. The biopsy is considered the gold standard for the diagnosis of celiac disease.

The only treatment for celiac disease is a strict gluten-free diet. This means avoiding all foods that contain wheat, barley, and rye, as well as avoiding cross-contamination with these grains. This diet can be challenging and require much education and support.

It’s important to note that even small amounts of gluten can cause damage to the small intestine, so it is crucial to avoid gluten in all forms.

While following a gluten-free diet can be challenging, it is highly effective in treating celiac disease. It allows the villi to heal and allows the body to absorb nutrients properly. With a strict gluten-free diet, most people with celiac disease will see improvement in their symptoms within a few weeks and complete resolution within several months.

However, it’s important to understand that celiac disease is a lifelong condition, and a gluten-free diet must be strictly followed for life to prevent the recurrence of symptoms and long-term complications.

It’s also important to note that celiac disease is not the only condition that gluten can trigger. Non-celiac gluten sensitivity, a condition that causes symptoms similar to celiac disease, but does not cause damage to the small intestine, may also benefit from a gluten-free diet.

Irritable Bowel Syndrome (IBS)

Irritable Bowel Syndrome (IBS) is a common condition that affects the large intestine (colon). It is a functional disorder, meaning there is no structural or biochemical problem with the intestine, but it is not working properly. It is characterized by abdominal pain, bloating, constipation, and diarrhea.

IBS is a chronic condition that can last for a long time and may require ongoing management. The symptoms of IBS can vary from person to person, and they can change over time. Some people may have mostly constipation, while others may have mostly diarrhea, and others may experience a mix of both.

There are several subtypes of IBS, which are classified based on the predominant symptoms:

  • IBS with constipation (IBS-C)
  • IBS with diarrhea (IBS-D)
  • IBS with alternating diarrhea and constipation (IBS-M)
  • Unclassified IBS (IBS-U)

The exact cause of IBS is not known, but it is thought to be related to a combination of factors, including:

  • Abnormal muscle contractions in the intestine (known as motility)
  • Sensitivity or pain in the intestine
  • An imbalance of gut bacteria
  • A history of infectious diarrhea (post-infectious IBS)
  • Psychological factors such as stress, anxiety or depression.

Diagnosis of IBS typically involves a combination of a physical examination, laboratory tests and a review of the patient’s medical history and symptoms. There is no specific test to diagnose IBS, so the diagnosis is made by excluding other possible causes of the symptoms, such as inflammatory bowel disease (IBD), celiac disease, or colon cancer.

Treatment for IBS usually involves a combination of lifestyle changes and medications.

Lifestyle changes that may help include:

  • Eating a healthy diet that is low in fat and high in fiber
  • Avoiding foods that trigger symptoms
  • Managing stress
  • Regular exercise

Medications that may be used to treat IBS include:

  • Antispasmodics to relieve abdominal pain and cramping
  • Laxatives to relieve constipation
  • Antidepressants to relieve pain and help improve motility
  • Probiotics to restore the balance of gut bacteria

It’s important to note that IBS can be a chronic condition, and treatment may require ongoing management. It’s also important to work closely with a healthcare provider to develop an individualized treatment plan that addresses the specific symptoms and needs of the person.

In addition, patients with IBS should be aware that the condition can be associated with other conditions such as Fibromyalgia, Migraine, and Chronic fatigue syndrome and it is important to be evaluated for these conditions as well.

If you have symptoms of IBS, it’s important to talk to your healthcare provider. They can help determine the cause of your symptoms and develop a treatment plan that is right for you.


Chronic diarrhea can also be caused by chronic infections, such as Clostridioides difficile (C. diff) or Giardia. These infections can cause inflammation in the intestine, leading to chronic diarrhea.


Certain medications, such as antibiotics and antacids, can cause diarrhea as a side effect.

Lactose Intolerance: Lactose intolerance is a common condition in which the body is unable to digest lactose, a sugar found in milk and other dairy products. This can lead to diarrhea.

Can Chronic Diarrhea Cause Orange Stool?

Chronic diarrhea is a condition that can lead to orange stool, caused by various factors including infections, food intolerances, and medication side effects. Identifying the underlying cause is crucial for effective treatment. Maintaining proper hydration, following a balanced diet, and discussing symptoms with a healthcare professional are essential steps in managing orange diarrhea causes and remedies.

Symptoms of Chronic Diarrhea

The main symptom of chronic diarrhea is frequent, loose stools. Other symptoms may include:

  1. Abdominal pain or cramping
  2. Gas or bloating
  3. Nausea or vomiting
  4. Weight loss
  5. Fatigue
  6. Dehydration

Diagnosis and Treatment of Chronic Diarrhea

Diagnosis of chronic diarrhea typically begins with a physical examination and a review of the patient’s medical history. The doctor may also order blood tests, stool tests, and imaging studies to help identify the underlying cause.

Treatment for chronic diarrhea will depend on the underlying cause. For example, if IBD causes diarrhea, treatment may involve medications to reduce inflammation and suppress the immune system. If the diarrhea is caused by celiac disease, treatment will involve a gluten-free diet.

If an infection causes diarrhea, antibiotics may be prescribed to clear the infection. If a medication causes diarrhea, the patient’s doctor may recommend switching to a different medication.

Probiotics, which are supplements containing beneficial bacteria, may help treat chronic diarrhea caused by infections or antibiotic use.

In cases where the cause of chronic diarrhea is not immediately clear, dietary changes may be recommended. This can include avoiding foods known to cause diarrhea, such as spicy foods or high-fat foods, and increasing the consumption of fiber-rich foods, such as fruits and vegetables.

Dietary changes may also be necessary for people with lactose intolerance, such as avoiding dairy products or taking lactase supplements.

In some cases, chronic diarrhea can be managed with over-the-counter medications, such as loperamide, which can slow food movement through the intestine and reduce diarrhea.

It’s important to note that chronic diarrhea can be a symptom of a more serious underlying condition.

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